Mettler Toledo - PRODUCT NEWS



New Optical Oxygen Sensors InPro 6880i for Enhanced Performance

METTLER TOLEDO's innovative optical DO sensors for biopharmaceutical
processes are fully steam-sterilizable, and combine accuracy and signal
stability with fast response time.

Optical sensors in the pharmaceutical industry
During fermentation processes, air feed and agitator speed are adjusted on the basis of the measured DO concentration value in order to achieve optimal growth conditions for the microorganisms. Indeed, excessive air feed can even damage the cells, besides leading to wastage of energy by the compressor.

In the pharmaceutical industry mammalian cell culture processes are on the increase. This technology enables the production of highly complex active substances. Mammalian cells react much more sensitively to changes in their environment than do bacterial cultures, and their growth is significantly slower. It is precisely in the case of batch runs of up to 5 weeks that the optical oxygen sensor can here fully demonstrate its inherent strength, namely negligible drift over time. The stable measurement enables batch-to-batch consistency and the maintenance
of optimal growth conditions. The new optical oxygen sensor InPro 6880i from METTLER TOLEDO can be used in small, autoclavable research bioreactorsas well as in full production-scale vessels. The identical characteristic in both cases facilitates and accelerates scale-up.

Measurement principle of the new optical sensors

At the heart of the optical sensor lies the oxygen-sensitive layer which contains immobilized marker molecules. These molecules respond to light by means of a chemo-optical mechanism which is influenced by the amount of oxygen diffusing into the layer. This effect allows determining the oxygen concentration in the sample media.

Main features of the optical oxygen sensors InPro 6880
The measurement technology of these optical oxygen sensors is designed to meet the most exacting demands. The 12 mm /Pg13.5 sensors are fully sterilizable and autoclavable. They offer reliable measurement accuracy and signal stability, ideal for biopharmaceutical process control. They fulfill the highest pharmaceutical requirements such as N5/Ra16 (Ra 0.4 µm / 16 µm) surface finish, sanitary design, FDA approval, and USP Class VI certified seals.

Increased process safety

Optical technology does not need any electrolyte solution and therefore simplifies handling. The built-in "Intelligent Sensor Management" (ISM®) technology allows for quick startup with "Plug & Measure" functionality and offers advanced diagnostics. The smart digital communication between sensor and transmitter ensures reliability for better process control. ISM helps in deciding whether a sensor is safe for reuse in the next batch or whether it is advisable to carry out maintenance such as membrane replacement.

Simplified start-up and maintenance ensures availability

The modular sensor design allows disconnecting the sensor shaft from the sensor head, which facilitates autoclaving handling and reduces maintenance effort and costs. The robust O2 sensitive layer offers increased lifetime and allows fast and easy replacement. Furthermore, the optical oxygen sensor offers maximum availability, since no polarization time is required.

For more information, please contact :-

Mettler-Toledo AG
Process Analytics
Im Hackacker 15, CH-8902 Urdorf, Switzerland
Tel. +41 44 729 62 11

February 2008

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